The SID mission is to advance the sciences relevant to skin disease through education.
These mouse models indicate that VDR functions independently of 1,25(OH)(2)D(3) in regulating hair-follicle cycling. Special issues published in Journal of Investigative Dermatology.
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IL-13 has been implicated in the pathogenesis of allergic diseases, including atopic dermatitis (AD). The aim of this study was to investigate the influence of IL-13 on the modulation of MMPs in human primary keratinocytes (KCs).
We aimed to develop an inducible transgenic model in which IL-13 can be expressed in the skin and to define the resulting dermal phenotype and mechanisms involved.
CiteScore: 8.1 ℹ CiteScore: 2019: 8.1 CiteScore measures the average citations received per peer-reviewed document published in this title. By using this site, you consent to the placement of these cookies. In vivo, oral administration of γ-PGA dramatically reduced the AD symptoms, similar to the response seen in the dexamethasone (Dex)-treated group. The Journal of Investigative Medicine considers unsolicited submissions of a variety of article types, including original research, reviews, and brief reports.
Pauli, M. Rosenblum, T.C. Werth, M. Liu, https://doi.org/10.1016/j.jid.2019.03.131, M. Brüggen, J. Strobl, F. Koszik, R. Naito, ... G. Stingl, https://doi.org/10.1016/j.jid.2019.03.132, https://doi.org/10.1016/j.jid.2019.03.133, https://doi.org/10.1016/j.jid.2019.03.134, https://doi.org/10.1016/j.jid.2019.03.135, M.T. Lennox, ... D.J.
Interestingly, the amounts of IL-8 stimulated by IL-17F were much higher than those stimulated by TNF-alpha or IL-17A.
HLA-DRB1*15:03 allelic frequencies were 50% for African patients, significantly higher than the control population (P<10(-3)), and 21% for the West Indians (nonsignificant).
Although the transfer of basophils to FcRγ(-/-) mice induced IgE-CAI, this induction was completely absent when basophils from FT-IV(-/-)/FT-VII(-/-) mice were transferred.
Matrix metalloproteinases (MMP) have been described to influence tissue remodeling and to facilitate cell migration through their ability to proteolyse the extracellular matrix.
To decline or learn more, visit our Cookies page. Although FT-IV(-/-) and FT-VII(-/-) mice exhibited comparable skin responses to wild-type mice, the FT-IV(-/-)/FT-VII(-/-) mice showed significantly impaired inflammation. Epidermolysis bullosa simplex (EBS) is an inherited skin disorder caused by mutations in keratins K5 (keratin 5) and K14 (keratin 14), with fragility of basal keratinocytes leading to epidermal cytolysis and blistering. Recently, it has been reported that IL-23 induces CCR6(+) γδ T T cells, which play a pivotal role in psoriasis-like skin inflammation in mice by producing IL-17 A and IL-22. The journal is currently publishing 139 volumes with the help of Elsevier Publication publisher. Descriptions of important findings that result from basic, translational, or clinical research are appropriate for submission.
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