Although MUA recordings allow one to monitor the activity of a large number of neurons, they do not allow identification of specific neuronal subtypes, the knowledge of which is often critical for understanding electrophysiological processes. By selecting the optimal parameters based on the stimulation timing, location, intensity, and duration of the TMS pulses, we can customize treatment to maximize an individual’s clinical response. Previous research on this question has relied on coarse anatomy (mapping large fiber pathways) or functional connectivity (mapping inter-regional statistical dependencies in ongoing activity). Across individuals, this relationship was found to be independent of the specific regions and functional systems probed. Arterioscler Thromb Vasc Biol. 2012; 4:122.
Keller, C. J., Bickel, S., Honey, C. J., Groppe, D. M., Entz, L., Craddock, R. C., Lado, F. A., Kelly, C., Milham, M., Mehta, A. D. Intrinsic functional architecture predicts electrically evoked responses in the human brain. professor of dermatology and, by courtesy, of health research and policy (epidemiology) Circulating markers of abdominal aortic aneurysm presence and progression. In the first section of this review, we discuss dysfunctional connectivity in affective salience, cognitive control, and default mode networks observed in MDD in association with characteristic symptoms of the disorder. The Stanford Diabetes Research Center is committed to providing support for the most innovative and unique research proposals related to diabetes in all disciplines. Golledge J, Tsao PS, Dalman RL, Norman PE. Our research focuses on abdominal aortic aneurysm (AAA), a life-threatening inflammatory vascular disease affecting one million of Americans. The low efficacy and one-size-fits-all treatment (with respect to timing, site, and intensity) stems from our lack of understanding of how TMS induces brain changes.
We observed excitability changes in regions anatomically and functionally closer to the stimulation site.
Comparison of the laminar CSD/MUA profile with the origins and terminations of cortical circuits allows activity in specific neuronal circuits to be inferred and then directly compared to hemodynamics. View details for DOI 10.1098/rstb.2013.0528, View details for Web of Science ID 000341695200007.
The fusiform gyrus (FG) is an important node in the face processing network, but knowledge of its causal role in face perception is currently limited. 2011; 39:2186-202. Despite recent advances, and unlike other established brain-mapping modalities (e.g. Sci Transl Med. Using two measures of network connectivity, cortico-cortical evoked potentials (indexing effective connectivity) and theta coherence (indexing functional connectivity), we found a stronger response to stimulation in regions that were highly connected to the stimulation site.
2002;22:2017-22. 2003;37:1067-74. Such signals would allow for treatment stratification and optimization. Nakahashi TK, Hoshina K, Tsao PS, Sho E, Sho M, Karwowski JK, Yeh C, Yang RB, Topper JN, Dalman RL. Corey Keller, MD, PhD is part of Stanford Profiles, official site for faculty, postdocs, students and staff information (Expertise, Bio, Research, Publications, and more). Here, we applied 10Hz direct electrical stimulation across several cortical regions in 14 human subjects (6 males) implanted with intracranial electrodes for seizure monitoring. Connectivity maps derived from electrical stimulation and from resting electrocorticography (ECoG) correlations showed similar spatial distributions for the same source node. The program's goal is to increase the number and diversity of successful physician researchers in the U.S. workforce. This combined phenotype was not associated with differences in symptoms or comorbidities, but nonetheless could be used to predict a poor response to psychotherapy, the best-validated treatment for PTSD. Contact us. Amit Etkin, MD, PhD, is a Professor of Psychiatry and Behavioral Sciences at Stanford University and a member of the Wu Tsai Neurosciences Institute. A., Crossley, N., Hallmayer, J., Fossati, S., Rothbaum, B. O., Marmar, C. R., Bullmore, E. T., O'Hara, R. Reproducibility in TMS-EEG studies: A call for data sharing, standard procedures and effective experimental control. David Chan, MD, PhD, is an Assistant Professor of Medicine at the Stanford School of Medicine, an investigator at the Department of Veterans Affairs, and a Faculty Research Fellow at the National Bureau of Economic Research. Pharmacotherapy and aspects of cognitive-behavioral therapy may be effective in ameliorating these symptoms in CD. 2003;11:417-9. Next, we highlight how CCEP mapping has begun to provide insight into the neural basis of non-invasive imaging signals. Thus, even under ideal conditions for the MUA to reliably predict the moment-to-moment activity of specific local neuronal ensembles, knowledge of the spike waveform of the underlying neuronal populations is necessary, but not sufficient. Ten different cortical areas and the hippocampus, including regions both inside and outside the seizure focus, were sampled.
Kitagawa T, Kosuge H, Uchida M, Iida Y, Dalman RL, Douglas T, McConnell MV. It is reasonable to expect that we can improve the efficacy of TMS. Research opportunity. Maegdefessel L, Azuma J, Toh R, Deng A, Merk DR, Raiesdana A, Leeper NJ, Raaz U, Schoelmerich AM, McConnell MV, Dalman RL, Spin JM, Tsao PS. Gow, D. W., Keller, C. J., Eskandar, E., Meng, N., Cash, S. S. Intracranial microprobe for evaluating neuro-hemodynamic coupling in unanesthetized human neocortex. In these regions, repeated cycles of stimulation trains and rest progressively altered the stimulation response. 2004;24:1916-21. In three of these patients, high density microelectrode arrays simultaneously recorded between 43 and 166 single units from a small (4 mm x 4 mm) patch of cortex. 2011 Jan 11. We conclude by proposing, with cautious optimism, the future incorporation of neuroimaging into clinical practice as a tool to aid in more targeted diagnosis and treatment guided by circuit-level connectivity dysfunction in patients with depression. Our philosophy is that MD program students should immerse themselves in a longitudinal bench or biomedical informatics research project for 2 years. Circulation. These results fill a missing gap in our understanding of stimulation-induced plasticity in humans. View details for DOI 10.1016/j.brs.2017.12.010. In many recordings there was also a decrease in broadband field potential activity during this same pre-discharge period. We compared the effects of single brief (100 μs) electrical pulses to the FG and non-face-selective visual areas on the speed and accuracy of detecting distorted faces. Together, these findings provide support for the neurophysiological fidelity of BOLD correlations and anticorrelations. Stanford also strives to provide “near peer” mentoring and training opportunities for the following educational levels: Why train to become a physician-scientist? His condition persisted despite treatment with risperidone 4 mg twice a day (BID), but improved dramatically on day 8 of hospitalization with the return of baseline mental function. Alicia Hamar (Undergraduate Student, Stanford University)
My 10 year research aims are to obtain this level of specificity and treatment response by: 1) Developing an integrated translational clinical research program.2) Identifying the specific neural mechanisms underlying repetitive stimulation-induced plasticity.3) Creating novel treatments with TMS based on experimentally-driven computational models of plasticity.
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